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AttributesValues
rdf:type
rdfs:label
  • Phenytoin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Phenytoin
UMLS_CUI
  • C0031507
CAS_Registry
  • 57-41-0
Accepted_Therapeutic_Use_For
  • Epilepsy
FDA_UNII_Code
  • 6158TKW0C5
Contributing_Source
  • FDA
Chemical_Formula
  • C15H12N2O2
Legacy_Concept_Name
  • Phenytoin
CHEBI_ID
  • CHEBI:8107
FULL_SYN
  • PhenytoinPTDCP00436
  • 5,5-Diphenyl-2,4-imidazolidinedioneSNNCI
  • DiphenylhydantoinSYNCI
  • PHENYTOINPTFDA6158TKW0C5
  • PhenytoinPTNCI
DEFINITION
  • A hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation.NCI
code
  • C741
is Has_Free_Acid_Or_Base_Form of
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