About: Thioredoxin-1 Inhibitor PX-12     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Thioredoxin-1 Inhibitor PX-12
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Thioredoxin-1 Inhibitor PX-12
UMLS_CUI
  • C0960559
PDQ_Open_Trial_Search_ID
  • 590656
PDQ_Closed_Trial_Search_ID
  • 590656
Legacy_Concept_Name
  • Thioredoxin-1_Inhibitor_PX-12
FULL_SYN
  • 1-Methylpropyl 2-Imidazolyl DisulfideSNNCI
  • PX-12CNNCI
  • Thioredoxin-1 Inhibitor PX-12PTNCI
DEFINITION
  • An orally bioavailable small molecule with potential antineoplastic activity. Thioredoxin-1 inhibitor PX-12 irreversibly binds to thioredoxin-1 (Trx-1) and inhibits its activity, which may result in growth inhibition and the induction of apoptosis. Overexpressed in many cancer cell types, the low molecular weight redox protein Trx-1 regulates transcription factor activity and inhibits apoptosis, promoting cell growth and survival; it also interacts with growth factors extracellularly to stimulate cell growth.NCI
code
  • C74082
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