About: Rexinoid NRX 194204     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Rexinoid NRX 194204
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Rexinoid NRX 194204
UMLS_CUI
  • C0967787
PDQ_Open_Trial_Search_ID
  • 592353
PDQ_Closed_Trial_Search_ID
  • 592353
Legacy_Concept_Name
  • Rexinoid_NRX_194204
FULL_SYN
  • Rexinoid NRX 194204PTNCI
  • AGN194204CNNCI
  • NRX194204CNNCI
DEFINITION
  • An orally bioavailable synthetic retinoid X receptor (RXR) agonist with potential antineoplastic and anti-inflammatory activities. Rexinoid NRX 194204 selectively binds to and activates RXRs. Because RXRs can form heterodimers with several nuclear receptors (NRs), RXR activation by this agent may result in a broad range of gene expression depending on the effector DNA response elements activated. Rexinoid NRX 194204 may inhibit the tumor-necrosis factor (TNF)-mediated release of nitric oxide (NO) and interleukin 6 (IL6) and may inhibit tumor cell proliferation. This agent appears to be less toxic than RAR-selective ligands.NCI
code
  • C74076
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