About: PNP-Expressing Ovine Atadenovirus FP253     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PNP-Expressing Ovine Atadenovirus FP253
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PNP-Expressing Ovine Atadenovirus FP253
NCI_META_CUI
  • CL383539
PDQ_Open_Trial_Search_ID
  • 590609
PDQ_Closed_Trial_Search_ID
  • 590609
Legacy_Concept_Name
  • PNP-Expressing_Atadenovirus_FP253
FULL_SYN
  • FP253-GDEPTCNNCI
  • FP253CNNCI
  • PNP-Expressing Ovine Atadenovirus FP253PTNCI
DEFINITION
  • An ovine atadenovirus encoding E. coli purine nucleoside phosphorylase (PNP) with prodrug activating activity. Under the control of a prostate-directed promoter, PNP-expressing atadenovirus vaccine FP253 expresses PNP in prostate tissue only after intraprostatic administration; this enzyme catalyzes systemically administered fludarabine prodrug into the active agent, 2-fluoroadenine. Localized prodrug activation provides prostate-targeted chemotherapy, potentially reducing systemic side effects.NCI
code
  • C74074
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