About: PI3K/mTOR Inhibitor BEZ235     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PI3K/mTOR Inhibitor BEZ235
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PI3K/mTOR Inhibitor BEZ235
UMLS_CUI
  • C2604817
PDQ_Open_Trial_Search_ID
  • 589292
PDQ_Closed_Trial_Search_ID
  • 589292
Legacy_Concept_Name
  • PI3K_Inhibitor_BEZ235
FULL_SYN
  • PI3K/mTOR Inhibitor BEZ235PTNCI
  • BEZ235CNNCI
DEFINITION
  • An orally bioavailable imidazoquinoline targeting the phosphatidylinositol 3 kinase (PI3K) and the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. PI3K/mTOR inhibitor BEZ235 inhibits PI3K kinase and mTOR kinase in the PI3K/AKT/mTOR kinase signaling pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K/mTOR-overexpressing tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.NCI
code
  • C74072
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