About: Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207
NCI_META_CUI
  • CL383482
PDQ_Open_Trial_Search_ID
  • 586104
PDQ_Closed_Trial_Search_ID
  • 586104
Legacy_Concept_Name
  • Live-Attenuated_Listeria_Encoding_Human_Mesothelin_Vaccine_CRS-207
FULL_SYN
  • Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207PTNCI
  • CRS-207CNNCI
DEFINITION
  • A recombinant Listeria-based cancer vaccine containing a live-attenuated strain of the facultative intracellular bacterium Listeria monocytogenes (Lm) expressing human mesothelin with potential immunostimulatory and antineoplastic activities. Upon administration of this vaccine, Listeria invade professional phagocytes within the immune system and express mesothelin, which may activate a cytotoxic T-lymphocyte (CTL) response against mesothelin-expressing tumor cells, resulting in tumor cell lysis. In addition, the Listeria vector itself may induce a potent innate and adaptive immunity unrelated to mesothelin expression. Mesothelin is a cell surface glycoprotein involved in cell adhesion and is overexpressed in many epithelial-derived cancers, including pancreatic, ovarian and lung cancers, and malignant mesotheliomas.NCI
code
  • C74055
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