About: Fluciclovine (18F)     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fluciclovine (18F)
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Indicator, Reagent, or Diagnostic Aid
Preferred_Name
  • Fluciclovine (18F)
NCI_META_CUI
  • CL383457
CAS_Registry
  • 222727-39-1
FDA_UNII_Code
  • 38R1Q0L1ZE
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 581382
PDQ_Closed_Trial_Search_ID
  • 581382
Chemical_Formula
  • C5H8FNO2
Legacy_Concept_Name
  • Anti-1-Amino-3-Fluorocyclobutane-1-Carboxylic_Acid
FULL_SYN
  • GE-148 (18F)CNNCI
  • Anti-1-Amino-3-[18F]Fluorocyclobutane-1-Carboxylic AcidSYNCI
  • (1R,3R)-1-Amino-3(18f)fluorocyclobutane-1-carboxylic acidSNNCI
  • FLUCICLOVINE F-18PTFDA38R1Q0L1ZE
  • Fluciclovine (18F)PTNCI
  • Fluciclovine (18F)SYNCI
  • [18F]FACBCABNCI
  • GE-148 F-18CNNCI
  • (18F)GE-148CNNCI
DEFINITION
  • A radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with potential diagnostic imaging use. Similar to most amino acids, anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid ([18]FACBC) appears to enter cells through the energy-independent L-type amino acid transporter (LAT) system. As an amino acid analogue, this agent is preferentially accumulated by tumor cells due to their increased metabolic needs; however, unlike naturally occuring amino acids, this non-natural amino acid-analogue radiotracer is not metabolized. Accordingly, [18]FACBC accumulates in tumor cells and can potentially be used to image tumors using positron emission tomography (PET).NCI
code
  • C74002
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