About: Pivampicillin Pamoate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pivampicillin Pamoate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pivampicillin Pamoate
UMLS_CUI
  • C2347522
CAS_Registry
  • 39030-72-3
FDA_UNII_Code
  • 5Z5TRG74EY
Contributing_Source
  • FDA
Chemical_Formula
  • C23H16O6.2C22H29N3O6S
Legacy_Concept_Name
  • Pivampicillin_Pamoate
FULL_SYN
  • PIVAMPICILLIN PAMOATEPTFDA5Z5TRG74EY
  • Pivampicillin PamoatePTNCI
DEFINITION
  • The pamoate salt form of a semisynthetic, orally active pivalate ester of ampicillin with antibacterial activity. Upon absorption, pivampicillin is hydrolyzed into its active form ampicillin by esterases. Ampicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.NCI
code
  • C73835
is Has_Salt_Form of
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