About: Cevipabulin Fumarate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cevipabulin Fumarate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cevipabulin Fumarate
UMLS_CUI
  • C2347606
CAS_Registry
  • 849550-69-2
FDA_UNII_Code
  • Q380BYV049
Contributing_Source
  • FDA
Chemical_Formula
  • C18H18ClF5N6O.C4H4O4.2H2O
Legacy_Concept_Name
  • Cevipabulin_Fumarate
FULL_SYN
  • CEVIPABULIN FUMARATEPTFDAQ380BYV049
  • TTI-237CNNCI
  • [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, 5-chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-, (2E)-2-butenedioate (1:1), dihydrateSNNCI
  • Cevipabulin FumaratePTNCI
DEFINITION
  • The fumarate salt of cevipabulin, a synthetic, water soluble tubulin-binding agent with potential antineoplastic activity. Cevipabulin appears to bind at the vinca-binding site on tubulin, but seems to act more similar to taxane-site binding agents in that it enhances tubulin polymerization and does not induce tubulin depolymerization. The disruption in microtubule dynamics may eventually inhibit cell division and reduce cellular growth., a small, water soluble, synthetic tubulin-binding agent with potential antineoplastic activity. Cevipabulin appears to bind at the vinca-binding site on tubulin, but seems to act more similar to taxane-site binding agents in that it enhances tubulin polymerization and does not induce tubulin depolymerization. The disruption in microtubule dynamics may eventually inhibit cell division and may reduce cellular growth.NCI
code
  • C73815
is Has_Salt_Form of
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