About: Pentoxifylline

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Pentoxifylline
rdfs:subClassOf	Antiplatelet Agent Alkaloids Phosphodiesterase Inhibitor
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Pentoxifylline
NSC_Code	637086
UMLS_CUI	C0030899
CAS_Registry	6493-05-6
FDA_UNII_Code	SD6QCT3TSU
Contributing_Source	FDA
ALT_DEFINITION	A drug used to prevent blood clotting and as a treatment that may help decrease weight loss in people with cancer.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41432
PDQ_Closed_Trial_Search_ID	41432
Chemical_Formula	C13H18N4O3
Legacy_Concept_Name	Pentoxifylline
FULL_SYN	PENTOXIFYLLINEPTFDASD6QCT3TSU PentoxifyllinePTNCI OxpentifyllineSYNCI PTXABNCI PentoxyphyllineSYNCI 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dioneSNNCI pentoxifyllinePTNCI-GLOSSCDR0000045369 TrentalBRNCI PentoxifyllinePTDCP09091
DEFINITION	A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility, and enhances blood flow. In addition, the increased level of cAMP in platelets inhibits platelet aggregation, which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune responses.NCI
code	C733
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