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AttributesValues
rdf:type
rdfs:label
  • Pomalidomide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pomalidomide
PubMedID_Primary_Reference
  • 16085014
UMLS_CUI
  • C2347624
CAS_Registry
  • 19171-19-8
FDA_UNII_Code
  • D2UX06XLB5
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of prostate cancer, multiple myeloma, and other types of cancer. Pomalidomide is a form of the drug thalidomide. It stops the growth of blood vessels, stimulates the immune system, and may kill cancer cells. Pomalidomide is a type of angiogenesis inhibitor and a type of immunomodulatory agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 653314
PDQ_Closed_Trial_Search_ID
  • 653314
Chemical_Formula
  • C13H11N3O4
Legacy_Concept_Name
  • Pomalidomide
FULL_SYN
  • 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimideSNNCI
  • 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dioneSNNCI
  • PomalidomidePTNCI
  • pomalidomidePTNCI-GLOSSCDR0000589401
  • CC-4047PTNCI-GLOSSCDR0000559141
  • CC-4047CNNCI
  • 4-AminothalidomideSYNCI
  • ActimidBRNCI
  • PomalystBRNCI
  • POMALIDOMIDEPTFDAD2UX06XLB5
DEFINITION
  • An orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF-alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody-dependent cellular cytotoxicity (ADCC). In addition, pomalidomide may inhibit tumor angiogenesis, promote cell cycle arrest in susceptible tumor cell populations, and stimulate erythropoeisis.NCI
code
  • C72560
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