About: Phosphatidylcholine-Bound Silybin     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Phosphatidylcholine-Bound Silybin
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Phosphatidylcholine-Bound Silybin
UMLS_CUI
  • C1873062
PDQ_Open_Trial_Search_ID
  • 558906
PDQ_Closed_Trial_Search_ID
  • 558906
Legacy_Concept_Name
  • Phosphatidylcholine-Bound_Silybin
FULL_SYN
  • Phosphatidylcholine-Bound SilybinPTNCI
  • Silybin-PhytosomeBRNCI
DEFINITION
  • An oral preparation of the flavonoid silybin with potential antioxidant and chemopreventive activities. Silybin, also known as silibinin, is a mixture of two stereoisomers, denoted silybin A and silybin B, and is the major active constituent of silymarin, a mixture of flavonolignans extracted from blessed milk thistle (Silybum marianum). Silybin modulates P-glycoprotein (P-gp)-mediated cellular efflux; has oxygen radical-scavenging effects; inhibits the arachidonic acid pathway; and inhibits various cytochrome P450 enzymes. This agent may also exhibit anti-angiogenic activity, possibly by inducing endothelial cell apoptosis via modulation of the transcription factor NF-kB, the Bcl-2 family of proteins, and caspases. Complexing silybin with phosphatidylcholine increases its bioavailability.NCI
code
  • C71883
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