About: Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes
rdfs:subClassOf
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes
NCI_META_CUI
  • CL376139
PDQ_Open_Trial_Search_ID
  • 560190
PDQ_Closed_Trial_Search_ID
  • 560190
Legacy_Concept_Name
  • Autologous_Anti-gp100_154-162_TCR_Gene-engineered_PBL
FULL_SYN
  • Autologous Anti-gp100:154-162 TCR Gene-Engineered PBLSYNCI
  • Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood LymphocytesPTNCI
  • Anti-p53 TCR-Transduced PBLSYNCI
DEFINITION
  • Human autologous peripheral blood lymphocytes (PBLs) transduced with a glycoprotein 100 (gp100) epitope-determined T cell receptor (TCR) gene, with potential antineoplastic activity. PBLs are isolated from a melanoma patient and pulsed with a viral vector encoding the TCR specific for amino acid residues 154-162 of gp100 (KTWGQYWQV). After expansion ex vivo, the transduced autologous PBLs, expressing this specific TCR, are reintroduced into the patient and bind to melanoma cells expressing the gp100 protein, which may result in specific cytotoxic T-lymphocyte (CTL) killing of gp100-expressing melanoma cells. gp100 is a melanocyte lineage-specific antigen overexpressed in melanomas.NCI
code
  • C71748
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