About: S-Adenosyl-L-Methionine Disulfate P-Toluene-Sulfonate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • S-Adenosyl-L-Methionine Disulfate P-Toluene-Sulfonate
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • S-Adenosyl-L-Methionine Disulfate P-Toluene-Sulfonate
NCI_META_CUI
  • CL376146
PDQ_Open_Trial_Search_ID
  • 560733
PDQ_Closed_Trial_Search_ID
  • 560733
Legacy_Concept_Name
  • S-Adenosyl-L-Methionine_Disulfate_P-Toluene-Sulfonate
FULL_SYN
  • S-Adenosyl-L-Methionine Disulfate P-Toluene-SulfonatePTNCI
  • SAMe Disulfate P-Toluene-SulfonateSYNCI
DEFINITION
  • The disulfate salt of the stable p-toluene-sulfonate complex of s-adenosyl-L-methionine (SAMe) with chemopreventive activity. SAMe disulfate p-toluene-sulfonate undergoes hydrolytic conversion to its active compound SAMe within cells. Although the mechanism of action is largely unknown, SAMe attenuates experimental liver damage and prevents experimental hepatocarcinogenesis. In addition, SAMe may reduce mitochondrial cytochrome C release, caspase 3 activation, and poly(ADP-ribose) polymerase cleavage, and attenuate okadaic acid-mediated hepatocyte apoptosis in a dose-dependent manner. SAMe is an essential compound in cellular transmethylation reactions and a precursor of polyamine and glutathione synthesis in the liver; SAMe deficiency is associated with chronic liver disease-associated decreases in the activity of methionine adenosyltransferase 1A (MAT1A), the enzyme that catalyzes the production of SAMe as the first step in methionine catabolism.NCI
code
  • C71745
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