About: PI3K Family Kinase Inhibitor XL147

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About: PI3K Family Kinase Inhibitor XL147 Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	PI3K Family Kinase Inhibitor XL147
rdfs:subClassOf	Protein Kinase Inhibitor
Semantic_Type	Pharmacologic Substance
Preferred_Name	PI3K Family Kinase Inhibitor XL147
NCI_META_CUI	CL376127
PDQ_Open_Trial_Search_ID	558909
PDQ_Closed_Trial_Search_ID	558909
Legacy_Concept_Name	PI3K_Family_Kinase_Inhibitor_XL147
FULL_SYN	PI3K Family Kinase Inhibitor XL147PTNCI XL147CNNCI
DEFINITION	An orally bioavailable small molecule, targeting the class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity. Class 1 PI3K kinase family inhibitor XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents including genotoxic agents and receptor tyrosine kinase inhibitors.NCI
code	C71705

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