About: Nanoparticle Albumin-Bound Docetaxel     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Nanoparticle Albumin-Bound Docetaxel
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Nanoparticle Albumin-Bound Docetaxel
NCI_META_CUI
  • CL376119
PDQ_Open_Trial_Search_ID
  • 557567
PDQ_Closed_Trial_Search_ID
  • 557567
Legacy_Concept_Name
  • Nanoparticle_Albumin-Bound_Docetaxel
FULL_SYN
  • Nab-DocetaxelSYNCI
  • Nanoparticle Albumin-Bound DocetaxelPTNCI
  • ABI-008CNNCI
DEFINITION
  • A nanoparticle albumin-bound formulation of the taxane docetaxel with antineoplastic activity. Docetaxel is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. This nanoparticle albumin-bound formulation solubilizes docetaxel without the use of the nonionic solubilizer Cremophor ELP, permitting the administration of larger doses of docetaxel while avoiding Cremophor ELP-associated toxicity.NCI
code
  • C71696
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