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AttributesValues
rdf:type
rdfs:label
  • Leucovorin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Leucovorin
UMLS_CUI
  • C0023413
CAS_Registry
  • 58-05-9
FDA_UNII_Code
  • Q573I9DVLP
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug used to lessen the toxic effects of substances that block the action of folic acid, especially the anticancer drug methotrexate. Folinic acid is used to treat some types of anemia and is also used with fluorouracil to treat colorectal cancer. It is also being studied in the treatment of other types of cancer and other conditions. Folinic acid is a form of folic acid. It is a type of chemoprotective agent and a type of chemosensitizing agent.NCI-GLOSS
Chemical_Formula
  • C20H23N7O7
Legacy_Concept_Name
  • Leucovorin
CHEBI_ID
  • CHEBI:15640
FULL_SYN
  • leucovorinPTNCI-GLOSSCDR0000045750
  • Folinic acidSYNCI
  • 5-FormyltetrahydrofolateSNNCI
  • folinic acidPTNCI-GLOSSCDR0000613202
  • LEUCOVORINPTFDAQ573I9DVLP
  • LeucovorinPTNCI
DEFINITION
  • A derivative of folic acid with chemoprotectant, antidote and synergistic activity. Leucovorin does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs, and is converted to a tetrahydrofolate, which is the necessary folate for purine and pyrimidine synthesis. As this agent allows for some purine/pyrimidine synthesis to occur, the toxic effects of folic acid antagonist-type chemotherapeutic drugs are counteracted while still permitting the antitumor activity of the folic acid antagonist through dihydrofolate reductase inhibition. This agent also potentiates the effects of 5-fluorouracil and its derivatives by stabilizing the binding of 5-fluorouracil's converted form fluorodeoxyuridylic acid to its target enzyme thymidylate synthase, thus prolonging drug activity.NCI
code
  • C71631
is Has_Free_Acid_Or_Base_Form of
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