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AttributesValues
rdf:type
rdfs:label
  • Lonaprisan
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Lonaprisan
PubMedID_Primary_Reference
  • 11150172
UMLS_CUI
  • C0963633
CAS_Registry
  • 211254-73-8
Accepted_Therapeutic_Use_For
  • Treatment of progesterone receptor positive breast cancer
FDA_UNII_Code
  • F5Z5EL4D26
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 579241
PDQ_Closed_Trial_Search_ID
  • 579241
Chemical_Formula
  • C28H29F5O3
Legacy_Concept_Name
  • Progesterone-Receptor_Antagonist_ZK_230211
FULL_SYN
  • 11 beta-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17 alpha-pregna-5,9-dien-3-oneSNNCI
  • ZK-PRASYNCI
  • LONAPRISANPTFDAF5Z5EL4D26
  • ZK 230211CNNCI
  • BAY86-5044CNNCI
  • Progesterone Receptor Antagonist ZK 230211SNNCI
  • LonaprisanPTNCI
DEFINITION
  • An orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity. Lonaprisan is a pure, highly receptor-selective progesterone receptor (PR) antagonist; binding of this agent to PRs inhibits PR activation and the associated proliferative effects. Unlike many other antiprogestins such as mifepristone, this agent does not appear to convert to an agonist in the presence of protein kinase A (PKA) activators and shows high antiprogestagenic activity on both progesterone receptor (PR) isoforms PR-A and PR-B.NCI
code
  • C71532
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