About: CD20-targeted Polypeptide TRU-015     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CD20-targeted Polypeptide TRU-015
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CD20-targeted Polypeptide TRU-015
NCI_META_CUI
  • CL375944
PDQ_Open_Trial_Search_ID
  • 570533
PDQ_Closed_Trial_Search_ID
  • 570533
Legacy_Concept_Name
  • CD20-targeted_Compound_TRU-015
FULL_SYN
  • CD20-targeted Polypeptide TRU-015PTNCI
  • TRU-015CNNCI
DEFINITION
  • A proprietary antibody-based single-chain polypeptide with B cell-depleting activity. Significantly smaller than a whole antibody, CD20-targeted polypeptide TRU-015 binds specifically to the B cell-specific cell surface antigen CD20 with full immunoglobulin Fv fragment-type target binding activity and full immunoglobulin Fc fragment-type effector function. This agent transiently depletes CD20-bearing B cells by inducing B cell -directed complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) and B cell apoptosis.NCI
code
  • C70797
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