About: Ramucirumab     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ramucirumab
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Ramucirumab
UMLS_CUI
  • C2742502
CAS_Registry
  • 947687-13-0
FDA_UNII_Code
  • D99YVK4L0X
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of breast cancer that has come back. It binds to receptors for a protein called vascular endothelial growth factor (VEGF). This keeps VEGF from binding to the receptors and may stop the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent and a type of monoclonal antibody.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 570535
PDQ_Closed_Trial_Search_ID
  • 570535
Legacy_Concept_Name
  • Anti-VEGFR-2_Fully_Human_Monoclonal_Antibody_IMC-1121B
FULL_SYN
  • RamucirumabPTNCI
  • Anti-VEGFR-2 Fully Human Monoclonal Antibody IMC-1121BSYNCI
  • ramucirumabPTNCI-GLOSSCDR0000648687
  • anti-VEGFR-2 fully human monoclonal antibody IMC-1121BPTNCI-GLOSSCDR0000648688
  • Monoclonal Antibody HGS-ETR2SYNCI
  • IMC-1121BPTNCI-GLOSSCDR0000648689
  • IMC-1121BCNNCI
  • RAMUCIRUMABPTFDAD99YVK4L0X
DEFINITION
  • A recombinant, fully human monoclonal antibody directed against human vascular endothelial growth factor receptor 2 (VEGFR-2) with antiangiogenesis activity. Ramucirumab specifically binds to and inhibits VEGFR-2, which may result in an in inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR-2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells.NCI
code
  • C70792
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