About: Cationic Liposome-Encapsulated Paclitaxel     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cationic Liposome-Encapsulated Paclitaxel
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cationic Liposome-Encapsulated Paclitaxel
UMLS_CUI
  • C1722887
PDQ_Open_Trial_Search_ID
  • 543136
PDQ_Closed_Trial_Search_ID
  • 543136
Legacy_Concept_Name
  • Cationic_Liposome-Encapsulated_Paclitaxel
FULL_SYN
  • LipoPacFBNCI
  • MBT-0206CNNCI
  • EndoTAG-1FBNCI
  • Cationic Liposome-Encapsulated PaclitaxelPTNCI
DEFINITION
  • A cationic liposome preparation of paclitaxel with antineoplastic activity. Paclitaxel, the active ingredient in cationic liposome-encapsulated paclitaxel, binds to tubulin and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis and cellular proliferation, and apoptosis. Cationic liposome encapsulation of paclitaxel allows the delivery of high doses of paclitaxel to target tissues while minimizing systemic toxicity. Tumor endothelial cells may preferentially bind and internalize cationic liposomes.NCI
code
  • C69130
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