About: Therapeutic Hemin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Therapeutic Hemin
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Therapeutic Hemin
UMLS_CUI
  • C0030316
PDQ_Open_Trial_Search_ID
  • 549706
PDQ_Closed_Trial_Search_ID
  • 549706
Legacy_Concept_Name
  • Therapeutic_Hemin
FULL_SYN
  • Therapeutic HeminPTNCI
  • Hemin for InjectionSYNCI
  • Hematin for InjectionSYNCI
  • PanhematinBRNCI
DEFINITION
  • A sterile, lyophilized powder of hemin, the Fe3+ oxidation product of heme (Fe2+), derived from processed red blood cells. Therapeutic hemin appears to inhibit delta-aminolevulinic acid (ALA) synthetase, a rate-limiting enzyme in the porphyrin/heme biosynthetic pathway, resulting in inhibition of the hepatic and/or marrow synthesis of porphyrin precursors. The mechanism by which therapeutic hematin produces symptomatic improvement in patients with acute episodes of the hepatic porphyrias has not been determined.NCI
code
  • C68925
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