About: Moxetumomab Pasudotox

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Attributes	Values
rdf:type	Class
rdfs:label	Moxetumomab Pasudotox
rdfs:subClassOf	CD22 Immunotoxin Pseudomonas Exotoxin Immunoconjugate nodeID://b646197 nodeID://b646198 nodeID://b646199 nodeID://b646200 nodeID://b646201 nodeID://b646202
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Moxetumomab Pasudotox
UMLS_CUI	C2346797
CAS_Registry	1020748-57-5
FDA_UNII_Code	2NDX4B6N8F
Contributing_Source	FDA
ALT_DEFINITION	A monoclonal antibody linked to a toxic substance. It is being studied in the treatment of some types of B-cell cancer. Anti-CD22 immunotoxin CAT-8015 is made in the laboratory. It binds to CD22, a protein on the surface of normal B cells and B-cell tumors, and kills the cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID	540032
PDQ_Closed_Trial_Search_ID	540032
Legacy_Concept_Name	Anti-CD22_Immunotoxin_CAT-8015
FULL_SYN	MOXETUMOMAB PASUDOTOXPTFDA2NDX4B6N8F HA22CNNCI CAT-8015PTNCI-GLOSSCDR0000543126 Anti-CD22 Immunotoxin CAT-8015SYNCI CAT-8015CNNCI GCR-8015CNNCI anti-CD22 immunotoxin CAT-8015PTNCI-GLOSSCDR0000562550 Immunotoxin CAT-8015SYNCI Moxetumomab PasudotoxPTNCI
DEFINITION	A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody covalently fused to a 38 KDa fragment of Pseudomonas exotoxin-A (PE38) with potential antineoplastic activity. The Fv portion of anti-CD22 immunotoxin CAT-8015 binds to CD22, a cell surface receptor expressed on a variety of malignant B-cells, thereby delivering the toxin moiety PE38 directly to tumor cells. Once internalized, PE38 induces caspase-mediated apoptosis via a mechanism involving mitochondrial damage and blocks translational elongation by binding to elongation factor 2 (EF-2). Anti-CD22 immunotoxin CAT-8015 exhibits a greater affinity for CD22 than its predecessor, anti-CD22 immunotoxin CAT-3888 (BL22 immunotoxin), and hence may be more effective against tumor cells expressing lower levels of CD22.NCI
code	C68819

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