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AttributesValues
rdf:type
rdfs:label
  • Neomycin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Carbohydrate
Preferred_Name
  • Neomycin
UMLS_CUI
  • C0027603
CAS_Registry
  • 1404-04-2
FDA_UNII_Code
  • I16QD7X297
Contributing_Source
  • FDA
ALT_DEFINITION
  • Antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C. It acts by inhibiting translation during protein synthesis.MSH2002_06_01
Legacy_Concept_Name
  • Neomycin
CHEBI_ID
  • CHEBI:7507
FULL_SYN
  • NEOMYCINPTFDAI16QD7X297
  • Neomycin ComplexSYNCI
  • NeomycinPTNCI
  • NeomycinPTDCP31674
DEFINITION
  • A broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.NCI
code
  • C683
is Has_Free_Acid_Or_Base_Form of
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