About: Ranibizumab     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ranibizumab
equivalentClass
Has_Target
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Ranibizumab
UMLS_CUI
  • C1566537
CAS_Registry
  • 347396-82-1
In_Clinical_Trial_For
  • Malignant Conjunctival Neoplasia
FDA_UNII_Code
  • ZL1R02VT79
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 544572
PDQ_Closed_Trial_Search_ID
  • 544572
Legacy_Concept_Name
  • Ranibizumab
FULL_SYN
  • RanibizumabPTNCI
  • Immunoglobulin G1, Anti-(Human Vascular Endothelial Growth Factor) Fab Fragment (Human-Mouse Monoclonal rhuFab V2 Gamma1 Chain), Disulfide With Human-Mouse Monoclonal rhuFab V2 Light ChainSYNCI
  • LucentisBRNCI
  • RANIBIZUMABPTFDAZL1R02VT79
DEFINITION
  • A second-generation, recombinant humanized IgG1 kappa monoclonal antibody fragment directed against human vascular endothelial growth factor (VEGF) alpha. Ranibizumab binds to VEGF alpha and inhibits VEGF alpha binding to its receptors, VEGFR1 and VEGFR2, thereby preventing the growth and maintenance of tumor blood vessels. The molecular weight of this agent (48 kD) is much smaller than the molecular weight of bevacizumab (MW ~149 kD), allowing complete penetration of the retina and the subretinal space following intravitreal injection. In contrast to other anti-VEGF aptamers such as pegaptanib, ranibizumab has a high specificity and affinity for all soluble human isoforms of VEGF.NCI
code
  • C67562
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