About: Taxane-Pocket Binding Agent

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About: Taxane-Pocket Binding Agent Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Taxane-Pocket Binding Agent
rdfs:subClassOf	Tubulin Binding Agent
Semantic_Type	Chemical Viewed Functionally
Preferred_Name	Taxane-Pocket Binding Agent
UMLS_CUI	C1883268
Legacy_Concept_Name	Taxane-Site_Binding_Agent
FULL_SYN	Taxane-Site Binding AgentSYNCI Taxane-Pocket Binding AgentPTNCI
DEFINITION	Any of a class of anti-mitotic compounds that bind to the taxane site of the beta-tubulin subunit, a region described as a binding pocket located within the middle domain and corresponding to an approximate residue sequence of 217-231. Specifically, these agents bind to a cysteine residue within the pocket, which is also the binding site for GTP. Agents binding at the taxane site promote the polymerization of dimers to form a very rigid and stable microtubule structure which is not readily disassembled. By interfering with microtubule dynamics these agents inhibit the normal turnover process essential during mitosis, thereby causing cell-cycle arrest and/or apoptosis.NCI
code	C67437
is rdf:first of	nodeID://b730823 nodeID://b730824
is rdfs:subClassOf of	Linoleyl Carbonate-paclitaxel Larotaxel Sagopilone Nanoparticle Albumin-Bound Docetaxel Taxol Analogue SID 530 Protein Stabilized Liposomal Docetaxel Nanoparticles Liposomal Docetaxel Paclitaxel Ceribate Docetaxel Lipid Microspheres Cephalomannine Baccatin III Epothilone A Patupilone BMS-184476 BMS-188797 Ortataxel Epothilone B Analogue DHA-Paclitaxel Epothilone D Tesetaxel Taxane Analogue TPI 287 Paclitaxel Preparation Docetaxel Anhydrous BMS-275183 CABAZITAXEL Oral Milataxel Docetaxel Emulsion ANX-514 Docetaxel Formulation CKD-810 Docetaxel-PNP 10-Deacetyltaxol PSMA-targeted Docetaxel Nanoparticles BIND-014

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