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AttributesValues
rdf:type
rdfs:label
  • Brivudine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Brivudine
NSC_Code
  • 633770
UMLS_CUI
  • C0163272
CAS_Registry
  • 69304-47-8
FDA_UNII_Code
  • 2M3055079H
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of infections caused by herpesvirus, including herpes-zoster (shingles). It belongs to the family of drugs called antivirals.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 577369
PDQ_Closed_Trial_Search_ID
  • 577369
Chemical_Formula
  • C11H13BrN2O5
Legacy_Concept_Name
  • Brivudine
FULL_SYN
  • (E)-5-(2-Bromovinyl)-deoxyuridineSNNCI
  • Bromovinyl-DeoxyuridineSYNCI
  • BVDUABNCI
  • RP101CNNCI
  • Trans-5-(2-Bromovinyl)-2'-deoxyuridineSNNCI
  • BRIVUDINEPTFDA2M3055079H
  • HelpinBRNCI
  • BrivudinePTNCI
  • brivudinePTNCI-GLOSSCDR0000335484
DEFINITION
  • A uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU treatment result in the decrease or prevention of chemoresistance. In addition, this agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells towards a pancreatic cancer cell line in vitro.NCI
code
  • C67088
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