About: Quinacrine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Quinacrine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Quinacrine Hydrochloride
NSC_Code
  • 14229
UMLS_CUI
  • C0282331
CAS_Registry
  • 6151-30-0
In_Clinical_Trial_For
  • Prostate cancer
FDA_UNII_Code
  • G6242H2NAA
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 531122
PDQ_Closed_Trial_Search_ID
  • 531122
Chemical_Formula
  • C23H30ClN3O.2ClH.2H2O
Legacy_Concept_Name
  • Quinacrine_Dihydrochloride
FULL_SYN
  • Atabrine DihydrochlorideSYNCI
  • Quinacrine HydrochloridePTNCI
  • Mepacrine DihydrochlorideSYNCI
  • Quinacrine DihydrochlorideSYNCI
  • QUINACRINE HYDROCHLORIDEPTFDAG6242H2NAA
  • SN 390CNNCI
  • 6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine DihydrochlorideSNNCI
DEFINITION
  • The dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53.NCI
code
  • C67059
is Has_Salt_Form of
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