About: Human Lactoferrin Peptide hLF1-11     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Human Lactoferrin Peptide hLF1-11
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Human Lactoferrin Peptide hLF1-11
UMLS_CUI
  • C1144139
In_Clinical_Trial_For
  • Infectious complications
PDQ_Open_Trial_Search_ID
  • 537368
PDQ_Closed_Trial_Search_ID
  • 537368
Legacy_Concept_Name
  • Human_Lactoferrin_1-11_Peptide
FULL_SYN
  • Human Lactoferrin Peptide hLF1-11PTNCI
  • hLF(1-11)ABNCI
DEFINITION
  • A synthetic peptide corresponding to the first 11 N-terminal amino acids of human lactoferrin (hLF1-11) with potential antimicrobial activity. Human lactoferrin, a 692 amino acid glycoprotein belonging to the transferrin family of metal-binding proteins, can be found in milk and other secretory fluids as well as in polymorphonuclear cells and leukocytes. Human lactoferrin plays a role in the innate defense of mucosal surfaces and neutrophils. Although the exact mechanism through which this peptide exerts its effect has yet to be fully elucidated, hLF1-11 may seize iron, thereby limiting the availability of free iron for microorganisms in the body. hLF1-11 appears to be effective against a variety of bacteria and fungi, including the multidrug-resistant Acinetobacter baumannii, multidrug-resistant Staphylococcus aureus, and fluconazole-resistant Candida albicans strains.NCI
code
  • C67046
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