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AttributesValues
rdf:type
rdfs:label
  • Moxalactam
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Moxalactam
UMLS_CUI
  • C0026651
CAS_Registry
  • 64952-97-2
FDA_UNII_Code
  • VUF6C936Z3
Contributing_Source
  • FDA
ALT_DEFINITION
  • Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39507
PDQ_Closed_Trial_Search_ID
  • 39507
Chemical_Formula
  • C20H20N6O9S
Legacy_Concept_Name
  • Moxalactam
CHEBI_ID
  • CHEBI:599928
FULL_SYN
  • MoxamBRNCI
  • MOXALACTAMPTFDAVUF6C936Z3
  • Ly 127935CNNCI
  • LatamoxefSYNCI
  • MoxalactamPTNCI
DEFINITION
  • A semisynthetic oxa-beta-lactam antibiotic, with antibacterial activity used mainly against gram-negative aerobic bacteria. Replacing the beta-lactam sulfur atom for an oxygen atom and the presence of the methyltetrazolethio moiety and the para-hydroxyphenylmalonyl group, increases the antibacterial activity of moxalactam. The 7-alpha-methoxy group and the para-hydroxyphenylmalonyl group increases the stability of this agent against beta-lactamases. The use of this agent has been associated with fatal bleeding events.NCI
code
  • C670
is Has_Free_Acid_Or_Base_Form of
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