About: Adenovirus-Interferon-Gamma TG1042     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Adenovirus-Interferon-Gamma TG1042
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Adenovirus-Interferon-Gamma TG1042
UMLS_CUI
  • C1832028
In_Clinical_Trial_For
  • Cutaneous B-and T-cell lymphoma
PDQ_Open_Trial_Search_ID
  • 530060
PDQ_Closed_Trial_Search_ID
  • 530060
Legacy_Concept_Name
  • Adenovirus-Interferon-Gamma_TG1042
FULL_SYN
  • Adenovirus-Interferon-Gamma TG1042PTNCI
  • TG1042ABNCI
  • Ad-IFNgABNCI
DEFINITION
  • A replication-defective adenoviral vector encoding human interferon-gamma (IFN-g) cDNA with potential antineoplastic and immunoregulatory activities. Upon intratumoral administration, the prolonged expression of IFN-g by adenovirus-interferon-gamma TG1042 promotes a T helper type 1 (Th1-type) immune response and inhibits the Th2-mediated cytokine production observed in many cutaneous lymphomas. IFN-g also mediates interleukin-12 (IL-12) production by antigen-presenting cells (APCs); activates macrophages, cytotoxic T-cells, and natural killer (NK) cells; upregulates major histocompatibility complex (MHC) molecules; and stimulates antibody-dependent cellular cytotoxicity (ADCC). Altogether, these IFN-g-mediated effects may result in an inhibition of tumor cell proliferation and tumor cell death.NCI
code
  • C66972
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