About: Belotecan Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Belotecan Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Belotecan Hydrochloride
UMLS_CUI
  • C0762739
CAS_Registry
  • 213819-48-8
FDA_UNII_Code
  • 01DZ4127G7
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of small cell lung cancer and other types of cancer. It blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of camptothecin analog and a type of topoisomerase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 537355
PDQ_Closed_Trial_Search_ID
  • 537355
Chemical_Formula
  • C25H27N3O4.ClH
Legacy_Concept_Name
  • Belotecan_Hydrochloride
FULL_SYN
  • Belotecan HydrochloridePTNCI
  • BELOTECAN HYDROCHLORIDEPTFDA01DZ4127G7
  • CKD602 HClCNNCI
  • belotecan hydrochloridePTNCI-GLOSSCDR0000630919
DEFINITION
  • The hydrochloride salt of the semi-synthetic camptothecin analogue belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.NCI
code
  • C66954
is Has_Salt_Form of
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