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AttributesValues
rdf:type
rdfs:label
  • Ofatumumab
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Ofatumumab
UMLS_CUI
  • C1832027
CAS_Registry
  • 679818-59-8
Accepted_Therapeutic_Use_For
  • chronic lymphocytic leukemia
FDA_UNII_Code
  • M95KG522R0
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat chronic lymphocytic leukemia (CLL) that has not gotten better with other chemotherapy. It is also being studied in the treatment of other types of cancer, including follicular non-Hodgkin lymphoma. Arzerra binds to CD20, a protein on the surface of normal B cells and most B-cell tumors. This may kill the cancer cells. It is a type of monoclonal antibody.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 530015
PDQ_Closed_Trial_Search_ID
  • 530015
Legacy_Concept_Name
  • Ofatumumab
FULL_SYN
  • ofatumumabPTNCI-GLOSSCDR0000537262
  • HuMax-CD20, 2F2ABNCI
  • ArzerraPTNCI-GLOSSCDR0000660188
  • ArzerraBRNCI
  • OFATUMUMABPTFDAM95KG522R0
  • GSK1841157CNNCI
  • HuMax-CD20FBNCI
  • HuMax-CD20PTNCI-GLOSSCDR0000559064
  • OfatumumabPTNCI
DEFINITION
  • A fully human, high-affinity IgG1 monoclonal antibody directed against the B cell CD20 cell surface antigen with potential antineoplastic activity. Ofatumumab binds specifically to CD20 on the surfaces of B cells, triggering complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) of B cells overexpressing CD20. The CD20 antigen, found on over 90% of B cells, B cell lymphomas, and other B cells of lymphoid tumors of B cell origin, is a non-glycosylated cell surface phosphoprotein that acts a calcium ion channel; it is exclusively expressed on B cells during most stages of B cell development.NCI
code
  • C66952
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