About: Crolibulin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Crolibulin
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Crolibulin
NCI_META_CUI
  • CL371131
CAS_Registry
  • 1000852-17-4
In_Clinical_Trial_For
  • Advanced Solid Tumors And Lymphomas
FDA_UNII_Code
  • 9ENT43KY91
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 536028
PDQ_Closed_Trial_Search_ID
  • 536028
Chemical_Formula
  • C18H17BrN4O3
Legacy_Concept_Name
  • EPC2407
FULL_SYN
  • Microtubule Inhibitor EPC2407SYNCI
  • EPC2407CNNCI
  • CROLIBULINPTFDA9ENT43KY91
  • CrolibulinPTNCI
DEFINITION
  • A small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.NCI
code
  • C66938
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software