About: Cabazitaxel     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cabazitaxel
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Cabazitaxel
UMLS_CUI
  • C2830183
CAS_Registry
  • 183133-96-2
Accepted_Therapeutic_Use_For
  • metastatic hormone-refractory prostate cancer
FDA_UNII_Code
  • 51F690397J
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used with prednisone to treat hormone-resistant prostate cancer that has spread and that had been treated with docetaxel. It is also being studied in the treatment of other types of cancer. Cabazitaxel blocks cell growth by stopping cell division and may kill cancer cells. It is a type of antimitotic agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 534131
PDQ_Closed_Trial_Search_ID
  • 534131
Chemical_Formula
  • C45H57NO14
Legacy_Concept_Name
  • XRP6258
CHEBI_ID
  • CHEBI:63584
FULL_SYN
  • CabazitaxelPTNCI
  • cabazitaxelPTNCI-GLOSSCDR0000682153
  • Taxoid XRP6258SYNCI
  • taxoid XRP6258PTNCI-GLOSSCDR0000682155
  • JevtanaPTNCI-GLOSSCDR0000682154
  • JevtanaBRNCI
  • XRP-6258CNNCI
  • 1-hydroxy-7beta,10beta-dimethoxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,13alpha-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-{[(tertbutoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoate]SNNCI
  • CABAZITAXELPTFDA51F690397J
  • RPR-116258ACNNCI
DEFINITION
  • A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).NCI
code
  • C66937
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