About: Lapatinib Ditosylate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Lapatinib Ditosylate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Lapatinib Ditosylate
UMLS_CUI
  • C1504917
CAS_Registry
  • 388082-78-8
Accepted_Therapeutic_Use_For
  • HER2 positive metastatic breast cancer
FDA_UNII_Code
  • G873GX646R
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used with another anticancer drug to treat breast cancer that is HER2 positive and has advanced or metastasized (spread to other parts of the body) after treatment with other drugs. Lapatinib ditosylate is also being studied in the treatment of other types of cancer. It is a type of ErbB-2 and EGFR dual tyrosine kinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 269659
PDQ_Closed_Trial_Search_ID
  • 269659
Chemical_Formula
  • C29H26ClFN4O4S.2C7H8O3S.H2O
Legacy_Concept_Name
  • Lapatinib_Ditosylate
FULL_SYN
  • LAPATINIB DITOSYLATEPTFDAG873GX646R
  • TykerbPTNCI-GLOSSCDR0000489115
  • lapatinib ditosylatePTNCI-GLOSSCDR0000539453
  • Lapatinib DitosylatePTDCP50669
  • TykerbBRNCI
  • Lapatinib DitosylatePTNCI
DEFINITION
  • The ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.NCI
code
  • C66878
is Has_Salt_Form of
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