About: Netilmicin Sulfate

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Netilmicin Sulfate
rdfs:subClassOf	AMINOGLYCOSIDES
Has_Free_Acid_Or_Base_Form	NETILMICIN
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Netilmicin Sulfate
UMLS_CUI	C0700550
CAS_Registry	56391-57-2
FDA_UNII_Code	S741ZJS97U
Contributing_Source	FDA
Chemical_Formula	2C21H41N5O7.5H2O4S
Legacy_Concept_Name	Netilmicin_Sulfate
CHEBI_ID	CHEBI:7529
FULL_SYN	Netilmicin SulfatePTNCI NETILMICIN SULFATEPTFDAS741ZJS97U
DEFINITION	The sulfate salt form of netilimicin, a semisynthetic, water soluble aminoglycoside antibiotic. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.NCI
code	C66237
is Has_Salt_Form of	NETILMICIN

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