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AttributesValues
rdf:type
rdfs:label
  • Lubiprostone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Lubiprostone
UMLS_CUI
  • C1684405
CAS_Registry
  • 333963-40-9
Accepted_Therapeutic_Use_For
  • Chronic Constipation
FDA_UNII_Code
  • 7662KG2R6K
Contributing_Source
  • FDA
Chemical_Formula
  • C20H32F2O5
Legacy_Concept_Name
  • Lubiprostone
FULL_SYN
  • LUBIPROSTONEPTFDA7662KG2R6K
  • LubiprostonePTNCI
  • AmitizaBRNCI
DEFINITION
  • A bicyclic fatty acid derived from prostaglandin E1 and a chloride channel activator with laxative activity. Upon intake, lubiprostone specifically binds to and activates the type 2 chloride channel (ClC-2) in the apical membrane of the gastrointestinal epithelium. This produces an efflux of chloride ions, thereby drawing water into the gastrointestinal lumen. The resulting increased amounts of intestinal fluid soften the stool, increase motility, and improve bowel movements.NCI
code
  • C66040
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