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AttributesValues
rdf:type
rdfs:label
  • Fuzlocillin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fuzlocillin
UMLS_CUI
  • C0060856
CAS_Registry
  • 66327-51-3
FDA_UNII_Code
  • J6UQP7JHOT
Contributing_Source
  • FDA
Chemical_Formula
  • C25H26N6O8S
Legacy_Concept_Name
  • Fuzlocillin
FULL_SYN
  • FuzlocillinPTNCI
  • FUZLOCILLINPTFDAJ6UQP7JHOT
DEFINITION
  • A semisynthetic acylureidopenicillin with antibacterial activity. Fuzlocillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.NCI
code
  • C65794
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