About: Colistimethate Sodium

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About: Colistimethate Sodium Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Colistimethate Sodium
rdfs:subClassOf	Antibacterial Agent
Has_Free_Acid_Or_Base_Form	COLISTIMETHATE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Colistimethate Sodium
UMLS_CUI	C0110462
CAS_Registry	8068-28-8
FDA_UNII_Code	XW0E5YS77G
Contributing_Source	FDA
Legacy_Concept_Name	Colistimethate_Sodium
CHEBI_ID	CHEBI:34650
FULL_SYN	Colistin Sodium MethanesulfonateSYNCI ColimyscineSYNCI COLISTIMETHATE SODIUMPTFDAXW0E5YS77G Pentasodium ColistinmethanesulfonateSYNCI W-1929CNNCI Colistimethate SodiumPTNCI Coly-MycinBRNCI
DEFINITION	The sodium salt of colistimethate, a broad-spectrum polymyxin antibiotic against most aerobic Gram-negative bacteria except Proteus bacteria. Colistimethate sodium contains the pentasodium salt of the penta(methanesulfonic acid) derivative of colistin A as the major component and a small proportion of the petasodium salt of the pentamethanesulfonate derivative of colistin B. Colistins are cyclic polypeptides produced from Bacillus colistinus or B. polymyxa and function as a surfactant which penetrates into and disrupts the bacterial cell membrane, thereby resulting in bactericidal effect.NCI
code	C65349
is Has_Salt_Form of	COLISTIMETHATE

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