About: Clioquinol     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Clioquinol
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Clioquinol
NSC_Code
  • 3531
UMLS_CUI
  • C0021978
CAS_Registry
  • 130-26-7
FDA_UNII_Code
  • 7BHQ856EJ5
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 653982
PDQ_Closed_Trial_Search_ID
  • 653982
Chemical_Formula
  • C9H5ClINO
Legacy_Concept_Name
  • Clioquinol
FULL_SYN
  • 5-Chloro-7-iodo-8-hydroxyquinolineSNNCI
  • IodochlorohydroxyquinolineSYNCI
  • 5-Chloro-7-iodo-quinolin-8-olSNNCI
  • CLIOQUINOLPTFDA7BHQ856EJ5
  • MycoquinBRNCI
  • AI3-16451CNNCI
  • ClioquinolPTNCI
DEFINITION
  • An orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. Clioquinol forms a stable chelate with copper (copper (II) ions), which inhibits the chymotrypsin-like activity of the proteasome; consequently, ubiquitinated proteins may accumulate in tumor cells, followed by tumor cell apoptosis and the inhibition of tumor angiogenesis. In addition, the clioquinol-copper complex appears to decrease the expression of androgen receptors (AR) in human copper-enriched prostate cancer cells. Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors.NCI
code
  • C65337
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