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AttributesValues
rdf:type
rdfs:label
  • Ceftobiprole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ceftobiprole
UMLS_CUI
  • C1100584
CAS_Registry
  • 209467-52-7
FDA_UNII_Code
  • 5T97333YZK
Contributing_Source
  • FDA
Chemical_Formula
  • C20H22N8O6S2
Legacy_Concept_Name
  • Ceftobiprole
FULL_SYN
  • CEFTOBIPROLEPTFDA5T97333YZK
  • CeftobiprolePTNCI
  • BAL9141CNNCI
  • RO 63-9141CNNCI
DEFINITION
  • A broad-spectrum, fifth-generation, pyrrolidinone cephalosporin with antibacterial activity. Ceftobiprole binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.NCI
code
  • C65306
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