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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Bitolterol
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Bitolterol
UMLS_CUI
  • C0053817
CAS_Registry
  • 30392-40-6
FDA_UNII_Code
  • 9KY0QXD6LI
Contributing_Source
  • FDA
Chemical_Formula
  • C28H31NO5
Legacy_Concept_Name
  • Bitolterol
CHEBI_ID
  • CHEBI:3133
FULL_SYN
  • BITOLTEROLPTFDA9KY0QXD6LI
  • BitolterolPTNCI
DEFINITION
  • A diester sympathomimetic amine with bronchodilator activity. As an ester prodrug, bitolterol is hydrolyzed by esterases to its active metabolite colterol (N-t-butylarterenol). Colterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle. This increases air flow and prevents bronchospasms and may eventually lead to an improvement of airway function.NCI
code
  • C65267
is Has_Free_Acid_Or_Base_Form of
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