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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Alefacept
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Alefacept
UMLS_CUI
  • C0962603
CAS_Registry
  • 222535-22-0
In_Clinical_Trial_For
  • Graft versus host disease; Cutaneous T-cell lymphoma; peripheral T-cell non-Hodgkin's lymphoma
FDA_UNII_Code
  • ELK3V90G6C
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat certain skin conditions and is being studied in the treatment of cutaneous (skin-related) T-cell cancer and T-cell non-Hodgkin lymphoma. Alefacept is made by combining part of an antibody with a protein that blocks the growth some types of T cells. It is a type of fusion protein and a type of immunosuppressant.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 531798
PDQ_Closed_Trial_Search_ID
  • 531798
Legacy_Concept_Name
  • Alefacept
FULL_SYN
  • ALEFACEPTPTFDAELK3V90G6C
  • AmevivePTNCI-GLOSSCDR0000572133
  • LFA3TIPSYNCI
  • AmeviveBRNCI
  • AlefaceptPTNCI
  • alefaceptPTNCI-GLOSSCDR0000538645
DEFINITION
  • A recombinant dimeric fusion protein consisting of the extracellular CD2-binding domain of the human leukocyte function-associated antigen 3 (LFA-3; CD58) linked to the Fc portion of human immunoglobulin G1 (IgG1) with potential immunosuppressive activity. Alefacept binds to the CD2 receptor expressed on the majority of T lymphocytes, blocking the binding of endogenous LFA-3, located on antigen-presenting cells (APCs), to the CD2 receptor; the activation and proliferation of T lymphocytes in response to LFA-3 binding is thus inhibited. In addition, binding of the IgG1 moiety of this agent to the Fc gamma receptor on the surface of natural killer (NK)cells may bridge NK cells and target T lymphocytes, initiating NK cell-mediated apoptosis of T lymphocytes.NCI
code
  • C65220
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