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AttributesValues
rdf:type
rdfs:label
  • Adalimumab
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Adalimumab
UMLS_CUI
  • C1122087
CAS_Registry
  • 331731-18-1
Accepted_Therapeutic_Use_For
  • Rheumatoid Arthritis, Crohn's Disease, Ankylosing Spondylitis, Psoriatic Arthritis
FDA_UNII_Code
  • FYS6T7F842
Contributing_Source
  • FDA
Legacy_Concept_Name
  • Adalimumab
FULL_SYN
  • D2E7CNNCI
  • HumiraBRNCI
  • ADALIMUMABPTFDAFYS6T7F842
  • LU200134CNNCI
  • Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimerSYNCI
  • AdalimumabPTNCI
DEFINITION
  • A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases.NCI
code
  • C65216
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