About: Mexiletine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Mexiletine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Mexiletine Hydrochloride
UMLS_CUI
  • C0600129
CAS_Registry
  • 5370-01-4
FDA_UNII_Code
  • 606D60IS38
Contributing_Source
  • FDA
ALT_DEFINITION
  • Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.MSH2002_06_01
Chemical_Formula
  • C11H17NO.HCl
Legacy_Concept_Name
  • Mexiletine
CHEBI_ID
  • CHEBI:6917
FULL_SYN
  • Mexiletine HydrochloridePTNCI
  • MEXILETINE HYDROCHLORIDEPTFDA606D60IS38
  • 1-Methyl-2-(2,6-xylyloxy)ethylamine HydrochlorideSNNCI
  • MexitilBRNCI
  • 1-(2,6-Dimethylphenoxy)-2-propanamine HydrochlorideSNNCI
  • Ko 1173 ClCNNCI
DEFINITION
  • The hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rise of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers. This slows nerve impulses in the heart and stabilizes the heartbeat. Mexiletine's anesthetic activity is due to its ability to block sodium influx in peripheral nerves, thereby reducing the rate and intensity of pain impulses reaching the central nervous system.NCI
code
  • C652
is Has_Salt_Form of
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