About: Apoptosis Inducer MPC-2130     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Apoptosis Inducer MPC-2130
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Apoptosis Inducer MPC-2130
UMLS_CUI
  • C1881499
PDQ_Open_Trial_Search_ID
  • 526178
PDQ_Closed_Trial_Search_ID
  • 526178
Legacy_Concept_Name
  • MPC-2130
FULL_SYN
  • Apoptosis Inducer MPC-2130PTNCI
  • MPC-2130CNNCI
DEFINITION
  • A broad-acting, apoptosis-inducing, small molecule with potential antineoplastic activity. Although the exact mechanism of action has yet to be fully elucidated, apoptosis inducer MPC-2130 exhibits proapoptotic activities in tumor cells, including membrane phosphatidylserine externalization, release of cytochrome C from mitochondria, caspase activation, cell condensation, and DNA fragmentation. In addition, because this agent is not a substrate for several types of multidrug resistance (MDR) ABC superfamily transporters, such as P-glycoprotein 1 (MDR-1), multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1/ABCG2), it may be useful in treating MDR tumors that express these particular MDR efflux pumps.NCI
code
  • C64781
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