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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Navitoclax
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Navitoclax
UMLS_CUI
  • C1831992
CAS_Registry
  • 923564-51-6
FDA_UNII_Code
  • XKJ5VVK2WD
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of lymphomas and other types of cancer. It blocks some of the enzymes that keep cancer cells from dying. It is a type of Bcl-2 family inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 523413
PDQ_Closed_Trial_Search_ID
  • 523413
Chemical_Formula
  • C47H55ClF3N5O6S3
Legacy_Concept_Name
  • ABT-263
FULL_SYN
  • navitoclaxPTNCI-GLOSSCDR0000674058
  • BcI-2 Family Protein Inhibitor ABT-263SYNCI
  • ABT-263PTNCI-GLOSSCDR0000533413
  • ABT-263CNNCI
  • NAVITOCLAXPTFDAXKJ5VVK2WD
  • A-855071.0CNNCI
  • NavitoclaxPTNCI
DEFINITION
  • An orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. Navitoclax selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w, which are frequently overexpressed in a wide variety of cancers, including those of the lymph, breast, lung, prostate, and colon, and are linked to tumor drug resistance. Inhibition of these apoptosis suppressors prevents their binding to the apoptotic effectors Bax and Bak proteins, thereby triggering apoptotic processes in cells overexpressing Bcl-2, Bcl-XL, and Bcl-w. This eventually reduces tumor cell proliferation.NCI
code
  • C64776
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