About: DT(388)IL3 Fusion Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • DT(388)IL3 Fusion Protein
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • DT(388)IL3 Fusion Protein
UMLS_CUI
  • C1831974
ALT_DEFINITION
  • A substance being studied in the treatment of myeloid leukemia (a disease in which too many immature non-lymphocyte white blood cells are found in the blood and bone marrow). DT388IL3 fusion protein is made by combining IL-3 with a toxic substance. The IL-3 attaches to the cancer cells and the toxic substance kills them.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 516002
PDQ_Closed_Trial_Search_ID
  • 516002
Legacy_Concept_Name
  • Diphtheria_Toxin_388_Interleukin-3_Fusion_Protein
FULL_SYN
  • DT(388)IL3 Fusion ProteinPTNCI
  • DT(388)-IL3 Fusion ProteinSYNCI
  • Diphtheria Toxin(388)-Interleukin-3 Fusion ProteinSYNCI
  • DT388IL3 fusion proteinPTNCI-GLOSSCDR0000530324
DEFINITION
  • A recombinant protein consisting of human interleukin 3 (IL3) fused to the first 388 amino acids of diphtheria toxin [DT(388)] with potential antineoplastic activity. Upon administration, the IL3 moiety of the DT(388)IL3 fusion protein binds to IL3 receptors on cells expressing the receptor. Subsequently, the DT(388) toxin moiety, containing both translocation and catalytic domains, translocates across the cell membrane via endocytosis; within the cytosol, the catalytic domain catalyzes the ADP-ribosylation of, and inactivates, translation elongation factor 2 (EF-2), resulting in the inhibition of translation during protein synthesis. IL3 may be overexpressed by acute myeloid leukemia (AML) cells.NCI
code
  • C64769
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