About: EGFR/HER2 Inhibitor AV-412     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • EGFR/HER2 Inhibitor AV-412
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • EGFR/HER2 Inhibitor AV-412
UMLS_CUI
  • C1831968
In_Clinical_Trial_For
  • Refractory or relapsed solid tumor malignancies
PDQ_Open_Trial_Search_ID
  • 513167
PDQ_Closed_Trial_Search_ID
  • 513167
Legacy_Concept_Name
  • AV-412
FULL_SYN
  • EGFR/HER2 Inhibitor AV-412PTNCI
  • AV-412CNNCI
  • MP-412CNNCI
DEFINITION
  • A second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization.NCI
code
  • C64627
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